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Browse 7,313 clinical trials for heart disease. Find studies that match your criteria and connect with research centers.
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Showing 3761-3780 of 7,313 trials
NCT01991093
Antiplatelet therapy with aspirin-clopidogrel reduces the risk of cardiovascular episodes after percutaneous coronary intervention (PCI) in patients with acute coronary syndromes. However, a significant number of patients experience recurrent events while on such therapy. The individual response to dual antiplatelet therapy is not uniform, and consistent findings across multiple investigations support the association between a lower degree of platelet inhibition, high on-treatment platelet reactivity, and the occurrence of atherothrombotic events \[1, 2\]. Particularly in diabetic patients, clopidogrel resistance is more prevalent compared with non-diabetics \[3,4\], which seems to contribute to the increased atherothrombotic risk in these patients compared with those without diabetes mellitus (DM) \[5\]. A number of platelet function instruments have now become available that are simple to use and can be utilized as point-of-care (POC) instruments in order to monitor antiplatelet therapy and potentially assess the risk of a recurrent event \[6\].
NCT03484286
A novel tool for self-care enhancement for heart failure (HF) patients has been developed. In this randomized controlled trial, patients will be randomized 1:1 to either receive the home-based tool (OPTILOGG) or standard care. The intervention will go on for 8 months, and outcomes are self-care, cardiovascular events (including emergency visits, admissions, number of in-hospital days).