Randomized Clinical Trial to Evaluate the Regenerative Capacity of CardioCell in Patients With Chronic Ischaemic Heart Failure (CIHF)

Exclusion Criteria

• •Other than ischemic cause of cardiomyopathy
• •Less than 3 months from any substantial therapeutic intervention (such as, e.g. CRT/ICD fitting or revascularization)
• •Less than 3 months from ACS
• •BMI lower than 18 or greater than 45kg/m2
• •Severe valvular heart disease or left ventricle aneurysm requiring aneurysmectomy or other structural interventions
• •Candidate for heart transplantation
• •Active or any history of malignancy or tumor
• •Moderate or severe immunodeficiency
• •Chronic immunosuppressive therapy
• •Acute or chronic infection
• •Coagulopathies
• •Known alcohol or drug dependence
• •Severe renal dysfunction (eGFR\<20mL/min)
• •Soft tissue disease or local infection in a place of required artery puncture
• •Pregnancy or breastfeeding
• •Females of childbearing potential who do not use a highly effective method of contraception
• •Females of childbearing potential in absence of a negative highly sensitive urine or serum pregnancy test
• •Participation in any other clinical research study that has not reached the primary efficacy endpoint or otherwise would interfere with the patient's participation in this project
• •Life expectancy \< 12 months
• •Any objective or subjective reason for inability to attend follow-up visits
• •Any concurrent disease or condition that, in the opinion of the investigator, would make the patient unsuitable for participation in the project