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Clinical Trials EpilepsyHouston

Epilepsy Clinical Trials in Houston

Find 107 clinical trials for epilepsy near Houston, Texas. Connect with research centers in your area.

All Epilepsy trials nationwide All trials in Houston

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Showing 81-100 of 107 trials

COMPLETEDNA< 1 mile

Bioequivalency Study of Levetiracetam 1g Under Fasted Conditions

NCT00826722

The objective of this study was to prove the bioequivalence of Levetiracetam 1000 mg Tablets under fasted conditions

Roxane Laboratories30 participantsStarted Jun 2007

Houston, Texas, United States

COMPLETEDPhase 3< 1 mile

Lethargic Depression Study

NCT00064467

This is a study of Major Depressive Disorder (MDD) in patients with decreased energy, pleasure and interests.

EpilepsyMajor Depressive Disorder (MDD)

GlaxoSmithKline268 participantsStarted Jun 2003

Beverly Hills, California, United States • Sherman Oaks, California, United States • Temecula, California, United States +21 more locations

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Data from ClinicalTrials.govTerms

Epilepsy Clinical Trials in Houston | 107 Studies | Clareo Health

COMPLETEDPhase 2< 1 mile

Pediatric Epilepsy Study in Subjects 1-24 Months

NCT00044278

This study will evaluate the long-term safety of LAMICTAL(lamotrigine)in subjects with partial seizures previously enrolled in protocol LAM20006 and in subjects 1-24 months of age who have never received LAMICTAL(LAMICTAL-naive). For LAMICTAL-naive subjects, LAMICTAL will be added to the subject's current epilepsy medications.

GlaxoSmithKline197 participantsStarted Sep 2000

Mobile, Alabama, United States • Tucson, Arizona, United States • Jonesboro, Arkansas, United States +67 more locations

COMPLETEDPhase 3< 1 mile

Lamotrigine Extended-Release In Elderly Patients With Epilepsy

NCT00516139

This study is being conducted to determine the safety and tolerability of lamotrigine (LTG) in elderly patients with epilepsy. This study will be carried out using an extended-release formulation of lamotrigine (LTG-XR) that will allow once-a-day dosing.

GlaxoSmithKline122 participantsStarted Aug 2007

Birmingham, Alabama, United States • Gilbert, Arizona, United States • Litchfield Park, Arizona, United States +60 more locations

COMPLETEDPhase 3< 1 mile

Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Primary Generalized Tonic-Clonic Seizures (PGTC) Seizures

NCT00104416

This study is being conducted to compare the efficacy and safety of LAMICTAL (lamotrigine) extended-release with placebo in the treatment of Primary Generalized Tonic-Clonic (PGTC) seizures. LAMICTAL extended-release is an investigational drug. Placebo tablets look like LAMICTAL extended-release tablets but do not contain active medication. In this study, LAMICTAL extended-release or placebo tablets will be added to current seizure treatments.

Epilepsy, Tonic-Clonic

GlaxoSmithKline153 participantsStarted Dec 2004

Anniston, Alabama, United States • Birmingham, Alabama, United States • Northport, Alabama, United States +143 more locations

COMPLETEDPhase 3< 1 mile

Retigabine (Adjunctive Therapy) Efficacy and Safety Study for Partial Onset Refractory Seizures in Epilepsy

NCT00232596

This Phase 3 study is being conducted to evaluate the efficacy and safety of retigabine dosed at 1200 mg/day, in three equally divided doses, compared with placebo in patients with epilepsy who are receiving up to three established antiepileptic drugs (AEDs).

GlaxoSmithKline306 participantsStarted Sep 2005

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Northport, Alabama, United States +51 more locations

COMPLETEDPhase 3< 1 mile

Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Partial Seizures

NCT00113165

This study is being conducted to compare the efficacy and safety of LAMICTAL (lamotrigine) extended-release with placebo in the treatment of partial seizures. LAMICTAL extended-release is an investigational drug. Placebo tablets look like LAMICTAL extended-release tablets but do not contain active medication. In this study, LAMICTAL extended-release or placebo tablets will be added to current seizure treatments.

EpilepsyEpilepsy, Partial

GlaxoSmithKline244 participantsStarted Oct 2004

Anniston, Alabama, United States • Birmingham, Alabama, United States • Northport, Alabama, United States +145 more locations

COMPLETEDPhase 4< 1 mile

A Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®)

NCT01278173

The purpose of the study is to evaluate the change in visual fields by means of automated static perimetry and to evaluate the change in retinal structure by means of spectral domain optical coherence tomography (SD-OCT) in adult patients with refractory complex partial seizures (CPS) being treated with vigabatrin (Sabril®)

Adult Refractory Complex Partial Seizures

Lundbeck LLC65 participantsStarted Dec 2010

San Francisco, California, United States • New Haven, Connecticut, United States • Dover, Delaware, United States +19 more locations

COMPLETEDPhase 3< 1 mile

Evaluation of the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures

NCT00735397

The purpose of this study was to evaluate the safety and tolerability of perampanel (up to 12 mg/day) given as adjunctive treatment in subjects with refractory partial seizures and to evaluate the maintenance of effect of perampanel for the control of refractory partial seizures.

Eisai Inc.1,218 participantsStarted Oct 2008

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Phoenix, Arizona, United States +236 more locations

COMPLETEDPhase 3< 1 mile

Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs

NCT00866775

This is an 18-week, double-blind, multicenter study with gradual conversion from previous antiepileptic therapy to eslicarbazepine acetate monotherapy in subjects with partial epilepsy.

Epilepsy With Simple or Complex Partial Onset Seizures

Sumitomo Pharma America, Inc.193 participantsStarted Apr 2009

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Mobile, Alabama, United States +103 more locations

TERMINATEDPhase 3146 miles

A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures

NCT00699283

Antiepileptic Drugs (AEDs) are the main treatment for epilepsy; however, only a limited number of AEDs are approved for use as monotherapy. The objective of this study is to evaluate the efficacy of BRV in the conversion of partial onset seizure patients from combination treatment to monotherapy.

UCB Pharma62 participantsStarted Aug 2008

Little Rock, Arkansas, United States • Garden Grove, California, United States • Loma Linda, California, United States +65 more locations

COMPLETEDPhase 3150 miles

Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy

NCT01128959

The purpose of this study is to assess the safety and tolerability of intravenous (IV) carbamazepine (CBZ) administered as multiple 15 minute infusions and a single 5 minute infusion to adult patients with epilepsy on stable higher doses of oral CBZ.

Lundbeck LLC108 participantsStarted Jun 2010

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Torrance, California, United States +26 more locations

COMPLETED189 miles

Detecting Generalized Tonic-Clonic Seizures With a Seizure Detection and Warning System in Epilepsy Patients

NCT02371200

Prospective study of an electromyography (EMG) based seizure detection and warning system for detecting generalized tonic-clonic (GTC) seizures.

EpilepsyGeneralized Tonic-Clonic Seizures

Brain Sentinel13 participantsStarted Apr 2015

Charleston, South Carolina, United States • San Antonio, Texas, United States

COMPLETEDPhase 3189 miles

Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures

NCT00419393

To provide continued treatment of Keppra XR (Levetiracetam XR) and to assess the long term safety of Keppra XR in subjects with partial onset seizures.

UCB Pharma190 participantsStarted Dec 2007

Dothan, Alabama, United States • Northport, Alabama, United States • Phoenix, Arizona, United States +32 more locations

COMPLETEDPhase 3214 miles

Conversion to Monotherapy Study With Keppra XR for Partial Seizures

NCT00419094

The primary objective of this study is to assess the efficacy of two doses of Keppra XR compared with a historical control as the placebo, in the monotherapy treatment of partial onset seizures.

UCB Pharma228 participantsStarted Aug 2007

Dothan, Alabama, United States • Northport, Alabama, United States • Phoenix, Arizona, United States +42 more locations

COMPLETEDPhase 3225 miles

Retigabine Efficacy and Safety Trial for Partial Onset Refractory Seizures in Epilepsy

NCT00235755

This Phase 3 study is being conducted to evaluate the efficacy and safety of retigabine dosed at 900 mg/day and 600 mg/day, in three equally divided doses, compared with placebo in patients with epilepsy who are receiving up to three established antiepileptic drugs (AEDs).

GlaxoSmithKline539 participantsStarted Dec 2005

Bethesda, Maryland, United States • Dallas, Texas, United States • Camperdown, New South Wales, Australia +67 more locations

COMPLETEDPhase 1/2225 miles

Evaluation of the Pharmacokinetics, Safety, and Tolerability of TPM XR as Adjunctive Therapy in Pediatric Subjects With Epilepsy

NCT01284530

Multidose, Open-label, Multi-center Study to examine the steady state pharmacokinetics of TPM XR, as well as, safety and tolerability of repeated oral dosing in pediatric subjects with epilepsy.

Supernus Pharmaceuticals, Inc.30 participantsStarted Jan 2011

Sacramento, California, United States • Loxahatchee Groves, Florida, United States • Miami, Florida, United States +7 more locations

COMPLETEDPhase 2235 miles

Open-label Study of Levetiracetam Intravenous Infusion in Children (1 Month-4 Years Old) With Epilepsy

NCT00505934

Keppra injection is approved in the US as adjunctive therapy in the treatment of partial onset seizures in adults with epilepsy. The objective of the current study is to assess the safety, tolerability, and pharmacokinetics, of this formulation in children aged 1 month to 4 years.

UCB Pharma SA19 participantsStarted May 2008

San Diego, California, United States • Buffalo, New York, United States • Philadelphia, Pennsylvania, United States +20 more locations

COMPLETEDNA567 miles

Radiosurgery or Open Surgery for Epilepsy Trial

NCT00860145

This study will compare radiosurgery (focused radiation, Gamma Knife Radiosurgery) with temporal lobectomy (standard surgical care) as a treatment of temporal lobe epilepsy. Patients who have seizures that begin in their temporal lobe that are not controlled with medications into the trial will be offered entry. Patients with a high likelihood of having their seizures controlled with open surgery will have treatment randomized between the standard surgery and radiosurgery. A prior study has shown that focused radiation (radiosurgery) may also reduce or eliminate seizures arising from the temporal lobe. The main study hypothesis is that radiosurgery is as safe and effective as temporal lobectomy in treating patients with seizures arising from the medial temporal lobe.

University of California, San Francisco61 participantsStarted Sep 2009

Birmingham, Alabama, United States • La Jolla, California, United States • Los Angeles, California, United States +11 more locations

COMPLETEDPhase 31105 miles

Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

NCT00150293

To determine long-term safety and efficacy of pregabalin in patients with partial seizures.

Seizure Disorder, Partial

Pfizer337 participantsStarted Mar 2002

Deakin, Australian Capital Territory, Australia • Camperdown, New South Wales, Australia • Chastwood, New South Wales, Australia +80 more locations

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