COPD Clinical Trials

Showing 1101-1120 of 1,501 trials

Spontaneous Breathing Trials Using Pressure-Support or T-Tube in Chronic Obstructive Pulmonary Disease Patients Weaning Mechanical Ventilation

NCT01464567

Weaning of mechanical ventilation (MV) is an essential part in management of patients with Chronic Obstructive Pulmonary Disease (COPD) when critically ill. The best strategy to be used has not been established. Objective: To compare the Spontaneous Breathing Trial (SBT) in Pressure Support Ventilation with SBT through "T" tube in weaning of MV in patients with COPD. Design: Randomized Clinical Trial. Methods: This study will include patients with COPD, admitted to the Intensive Care Unit of Hospital Nossa Senhora da Conceição, undergoing MV for at least 48 hours. When considered by the care team ready for SBT, they will be randomized to one of the following strategies: SBT in Pressure Support or SBT through "T" Tube. The primary endpoint of this study will be the reduction in the days spent on MV. Other outcomes measured will be mortality, extubation and success rate, time to weaning of MV, length of ICU stay and incidence of tracheostomy.

Weaning of Mechanical VentilationChronic Obstructive Pulmonary Disease

Hospital Nossa Senhora da Conceicao190 participantsStarted Jan 2012

Porto Alegre, Rio Grande do Sul, Brazil • Porto Alegre, Rio Grande do Sul, Brazil

COMPLETEDPhase 3

Clinical Trial to Assess Rate of Onset of Bronchodilator Action in Severe Stable Chronic Obstructive Pulmonary Disease (COPD) Patients

NCT00435760

This trial evaluates the rate of onset of bronchodilator action of aclidinium bromide compared to placebo and tiotropium in patients with severe COPD after a single dose treatment.

Chronic Obstructive Pulmonary Disease (COPD)

AstraZeneca115 participantsStarted Feb 2007

London, United Kingdom

Spontaneous Breathing Trials Using Pressure-Support or T-Tube in Chronic Obstructive Pulmonary Disease Patients Weaning Mechanical Ventilation

Clinical Trial to Assess Rate of Onset of Bronchodilator Action in Severe Stable Chronic Obstructive Pulmonary Disease (COPD) Patients

Related Searches

Associations Between Air Pollutants Exposures and Respiratory System Study

Program of Integrated Care for Patients With Chronic Obstructive Pulmonary Disease and Multiple Comorbidities

Effects of Occupational Therapy in COPD

Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Predictive Questionnaires for Risk of Acute COPD (Chronic Obstructive Pulmonary Disease) Exacerbations

Effect of Home-base Exercise With Conical-PEP Device on Physical Performance and Quality of Life in COPD

Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe COPD

Symbicort Turbuhaler 30/60 Special Clinical Experience Investigation for Long-term Use for Chronic Obstructive Pulmonary Disease (COPD) Patients

A Multi-center Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of R7103 Following Repeated Inhalation in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease

Efficacy and Safety of Roflumilast in Japanese Patients Older Than 40 Years With Chronic Obstructive Pulmonary Disease (APTA-2217-06)

Safety and Benefits of Using Laryngeal Mask Airway to Keep Airway Potency During Fiber-optic Bronchoscopy

Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics

A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD

High Risk Populations Among COPD Patients in Japan

Trial of E-Health Platform Supported Care vs Usual Care After Exacerbation of COPD

A Study to Investigate the Bronchodilatory Effect of NVA237 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Effects on Respiratory Patterns and Patient-ventilator Synchrony Using Pressure Support Ventilation

The Effects of RPL554 on Top of Standard COPD Reliever Medications