Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections

Exclusion Criteria

• •1. Informed consent following inclusion expected to be unobtainable
• •2. Inability to read and understand Danish to a degree that allows valid informed consent and completion of trial assessments
• •3. Pregnant or breastfeeding patients
• •4. Involuntary admission under the psychiatric law
• •5. Admitted to hospital or undergone surgery during the 14 days prior to admission
• •6. Expected initiation of palliative care within 48 hours of randomization
• •7. Previous randomization into the current trial
• •8. Admitted to ICU or expected transfer to ICU within 2 hours
• •9. Previous severe anaphylaxis
• •10. Any other condition deemed by the investigator to compromise patient safety or trial integrity (e.g., severe coagulopathy, uncontrolled bleeding, diabetic ketoacidosis)