Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment

Exclusion Criteria

• •Patients who have previously used tetracycline and furazolidone antibiotics to eradicate infection with H. pylori.
• •Contraindications to study drugs.
• •Substantial organ impairment, severe or unstable cardiopulmonary or endocrine disease.
• •Constant use of anti-ulcer drugs ( including taking proton-pump.inhibitors(PPI) within 2 weeks before the \[13C\] urea breath test), antibiotics or bismuth complexes (more than 3 times /1 month before screening).
• •Pregnant or lactating women.
• •Underwent upper gastrointestinal Surgery.
• •Dysphagia.
• •Evidence of bleeding or iron efficiency anemia.
• •A history of malignancy.
• •Drug or alcohol abuse history in the past 1 year.
• •Systemic use of corticosteroids, non steroidal anti-inflammatory drugs, anticoagulants, platelet aggregation inhibitors (except the use of aspirin for less than 100 mg/d).
• •Mental disorder.
• •Enrolled in other clinical trials in the past 3 months.
• •Refuse to sign informed consent.