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Metabolic Adaptations to High-fat Diet | Clinical Trials | Clareo Health

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TERMINATEDNANCT06537401

Metabolic Adaptations to High-fat Diet

The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood. The primary question this study seeks to address is what is the effect ...

Lead sponsor: George Washington University•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

George Washington University

Age

20 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Males or Females between the ages of 20 and 45 years
•Body mass index (BMI) of 18.5-29.9 kg/m2
•Low risk for medical complications as determined by physical activity readiness questionnaire (PARQ).
•Low risk for food insecurity via the Hunger Vital Sign screener

Exclusion Criteria

•Currently taking any antioxidant supplementation, prescription non-steroidal anti- inflammatory drugs, antibiotics, steroids, probiotics, medications for management of cholesterol, diabetes, body weight/obesity, or are undergoing transgender hormone therapy.
•Currently pregnant (verified by urine pregnancy test)
•Any history of disordered eating (i.e., anorexia nervosa, bulimia nervosa, binge eating disorder, etc.) or high risk for disordered eating via validated questionnaire (SCOFF)
•Any history of gastrointestinal diseases (i.e., gastroesophageal reflux disease, irritable bowel syndrome, Celiac disease, Crohn's disease, or lactose intolerance)
•Allergies to wheat or gluten, milk, soy, tree nuts (e.g., almonds, walnuts, pecans), or peanuts.
•Followed a ketogenic diet within the last three months
•Instructed by a medical provided to avoid a high-fat diet due to cardiovascular disease risk.
•Cardiorespiratory fitness (VO2max) greater than the 90th percentile for age and sex

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 26, 2025Terms

Trial snapshot

StatusTERMINATED

PhaseNA

Enrollment2

Start dateAug 2024

Last updatedAug 26, 2025

Condition

Adiposity Insulin Sensitivity Impaired Glucose Tolerance Metabolic Disturbance

Locations shown

George Washington University School of Public Health

Washington D.C., District of Columbia

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 26, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions