High Intensity Interval Training and Insulin Sensitivity in Type 2 Diabetes

Exclusion Criteria

• •Type 1 diabetes
• •Patients with congestive heart failure and and/or severe renal and or liver insufficiency
• •Contraindications for MRI/MRS examination
• •Active diabetic foot
• •Polyneuropathy or retinopathy
• •Signs of active liver or kidney dysfunction
• •BMI \>35 kg/m2
• •Exogeneous insulin therapy
• •Use of antidiabetic medication other than metformin or sulfonylurea derivatives treatment within 3 months before screening
• •Use of SGLT2 inhibitors
• •Unstable body weight (variations \>5kg in the last 3 months)
• •Ongoing weight loss diet or use of weight loss agents
• •Uncontrolled hypertension
• •Engagement in regular exercise program or any other medical condition that will impede the safe performance of the experiments