PRogrammed Versus Modified Natural Cycle After Euploid Failed Embryo Transfer

Exclusion Criteria

• •1. More than 1 prior unsuccessful frozen embryo transfer cycle.
• •2. The prior FET failure having had resulted in a clinical loss or ectopic pregnancy
• •3. Previously cancelled frozen embryo transfer cycle for inadequate endometrial response.
• •4. Patients who required a different route of estrogen administration in the prior programmed cycle (vaginal, transdermal, intramuscular).
• •5. PGT-A analysis of the available embryo for transfer performed prior to January 1, 2017.
• •6. Anovulatory or oligo-ovulatory patients unable to undergo modified natural endometrial preparation.
• •7. Patients with an endometrial thickness \< 7 mm prior to progesterone start in prior cycle.
• •8. History of hypertensive disorders of pregnancy, including gestational hypertension, preeclampsia, and eclampsia.
• •9. Mullerian anomalies, excluding arcuate uterus and repaired septum.
• •10. No euploid embryos available for transfer.
• •11. Concurrent submucosal fibroids, unrepaired uterine defects or present indication for uterine surgery.
• •12. Communicating hydrosalpinx without plans for surgical correction prior to study enrollment.
• •13. Failure of patient to agree to enrollment in study with written consent.
• •14. Concurrent pregnancy.
• •15. Concomitant use of adjunctive therapies for endometrial proliferation or receptivity, including anticoagulation and antihistamines. These must be discontinued upon enrollment.
• •16. Embryo planned to be used for transfer generated from surgically obtained sperm.
• •17. Recurrent/persistent endometrial fluid in prior cycles visualized on the majority of transvaginal ultrasound monitoring.
• •18. Third party reproduction patients (donor sperm sources can be included).