pBFS-guided iTBS Over the Left DLPFC for Chronic PSCI

Exclusion Criteria

• •Have been diagnosed with cognitive impairment resulting from other disorders including mild cognitive impairment (MCI), Alzheimer's disease (AD), vascular dementia (VCI), acquired traumatic brain injury (TBI);
• •have history of drug or alcohol abuse;
• •have history of other psychiatric disorders or currently experiencing severe depression or anxiety (HAMD-17 \> 24 or HAMA ≥ 29);
• •be with severe primary diseases in the circulatory, respiratory, digestive, urinary, endocrine, or hematopoietic systems that cannot be controlled by conventional medications;
• •be with malignant hypertension or malignant tumors；
• •be with severe infections, water and electrolyte imbalances, or acid-base disturbances；
• •be with severe aphasia (NIHSS\_language ≥ 2 points), dysarthria (NIHSS\_dysarthria ≥ 2 points), impaired consciousness (NIHSS\_level of consciousness ≥ 1 point), audiovisual impairments, or those unable to cooperate with the assessment or treatment；
• •be with a history of seizures;
• •be with contraindications to TMS treatment, such as having an implanted electronic device (e.g. cardiac pacemaker, cochlear implant);
• •be with contraindications to MRI, such as the presence of ferromagnetic metallic implants or claustrophobia;
• •have received neuromodulation therapy such as TMS, transcranial electrical stimulation, or transcranial focused ultrasound within the past 3 months prior to enrollment;
• •be concurrently participating in other clinical trials;
• •be pregnant women or those planning to become pregnant;
• •be with other abnormalities as determined by the investigator that do not meet the trial criteria.