The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.

Exclusion Criteria

• •1. Bilateral strokes (infarcts and/or hematoma)
• •2. Other co-existent neuromuscular disorders affecting upper extremity motor impairment.
• •3. History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study.
• •4. Uncontrolled hypertension despite medical treatment(s) at the time of randomization, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and randomized later).
• •5. Presence of any MRI/rTMS risk factors including but not limited to:
• •1. an electrically, magnetically, or mechanically activated metallic or nonmetallic implant including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system.
• •2. a non-fixed metallic part in any part of the body, including a previous metallic injury to the eye.
• •3. history of seizure disorder before stroke or seizure after stroke.
• •4. preexisting scalp lesion or bone defect or hemicraniectomy.
• •6. Concurrent enrollment in another interventional stroke recovery study.
• •7. Concerns that the subject cannot comply with study procedures and visits.
• •8. Pregnant individuals