Ascending Single-Dose and Multiple-Dose Study to Evaluate RJ4287 in Healthy Subjects

Exclusion Criteria

• •History of thyroid disorder or abnormal thyroid function tests at screening
• •Abnormal abdominal ultrasound findings with clinical significance
• •Sensitivity to thyroid medication or history of sensitivity to a similar study drug(eg.MGL-3196)
• •History of sensitivity to a similar study drug
• •Major surgical procedure, previous gastrointestinal surgery, vagotomy, bowel resection or any surgical procedure that may interfere with peristalsis, pH or absorption in the gastrointestinal tract within 6 months prior to screening
• •Subjects who, in the judgement of the investigator, have a condition that affects the absorption, distribution, metabolism and excretion of the drug (e.g. gastrointestinal dysfunction, peptic ulcer, gastrointestinal surgery, etc.) or who are unable to comply with a uniform diet during the trial
• •Taken any prescription medication, over-the-counter medication, any vitamin product or herbal remedy within 1 month prior to screening
• •Subjects with any current or previous illness that, in the opinion of the Investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject or that could prevent, limit, or confound the protocol specified assessments or study results interpretation
• •History of regular use nicotine or alcohol，unable to abstain from smoking and alcohol during the trial
• •Previous blood donation or blood loss of more than 400 mL within 3 months prior to taking the study drug
• •Had consumed a special diet (including popcorn, dragon fruit, mango, grapefruit, orange, etc.) or alcohol within 2 weeks before taking the study drug, or had strenuous exercise
• •Taken an experimental drug or other experimental treatment within 3 months prior to screening, or being involved in any other interventional clinical trial
• •Nursing female subjects
• •Any other condition that, in the opinion of the investigator or sponsor, makes the subject unsuitable for inclusion in the study