Ascending Single-Dose Study to Evaluate VIA-3196 in Healthy Subjects

Exclusion Criteria

• •History of thyroid disorder or abnormal thyroid function tests at screening. Repeat testing is allowed at the discretion of the Investigator.
• •History of unexplained syncope.
• •History of hepatobiliary disease; or AST, ALT or direct bilirubin greater than the upper limit of reference range at screening.
• •Positive screening test for HIV antibody, Hepatitis B surface antigen or Hepatitis C antibody.
• •Abnormal screening ECG: including machine-read QTc \>450 msec, QRS \>110 msec, intermittent bundle branch block, frequent premature atrial or premature ventricular contractions, or any rhythm other than normal sinus rhythm which is interpreted by the Investigator to be clinically significant.
• •History of sensitivity to a similar study drug (e.g., Karo Bio KB2115 or Metabasis MB7811), or a history of important drug or other allergy (except for untreated, asymptomatic seasonal allergies at time of dosing).
• •Sensitivity to thyroid medication.
• •History of asthma, or intolerance to beta-blockers.
• •Use of acetaminophen within 7 days before dosing and throughout the study.
• •History of regular use of tobacco or nicotine containing products within the past 6 months.
• •Positive urine drug screen or alcohol test at screening.