LK101 Combined With PD-1 or PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer

Inclusion Criteria

• •signed informed consent;
• •≥18years, male or female;
• •cohort1: Histologically/cytologically confirmed locally advanced or metastastic Non-small lung carcinoma (NSCLC), and received systemic treatment for recurrence/metastasis ≤3 lines; cohort2: Histologically/cytologically confirmed extensive small-cell lung carcinoma (ES-SCLC); Cohort 1 and Cohort 2 required patients progressed/recurrenced after anti-PD-1/PD-L1treatment;
• •Cohort 3: Histologically/cytologically confirmed locally advanced or metastatic non-small cell lung cancer (NSCLC) with no driver gene mutation and have PD-L1 expression, and who have not experienced disease progression after receiving chemotherapy combined with an anti-PD-1 therapy.
• •Life expectancy of more than 3 months;
• •Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1;
• •At least one measurable lesion according to RECIST 1.1;
• •The sequencing of tumor were qualified;
• •According to the invistigators' judgment, venous vascular conditions can meet the needs of apheresis;
• •For adequate organ function, the patients need to meet the following laboratory indexes:
• •* hematologic functions(No blood transfusion or treatment with blood components and without granulocyte colony stimulating factor in the past 14 days.):
• •* the absolute value of neutrophils (ANC) ≥ 1.5x109/L;
• •* the platelet count was ≥ 90x109/L;
• •* the hemoglobin \> 9g/dL;
• •* Hepatic functions:
• •* Total bilirubin ≤ 1.5 × normal upper limit (ULN); patients with liver metastasis allow ≤ 3 × ULN;
• •* aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × ULN (patients with liver metastasis allow ALT or AST ≤ 5 × ULN);
• •* renal
• •* Serum creatinine ≤ 1.5 × ULN and creatinine clearance (calculated by Cockcroft-Gault formula) ≥ 50ml;
• •* patients with urinary protein ≥ + + and confirmed 24-hour urinary protein quantity \> 1.0g;
• •* Coagulation function is good, defined as international standardized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN;
• •* Normal thyroid function is defined as thyroid stimulating hormone (TSH) within the normal range. If the baseline TSH is beyond the normal range, subjects with total T3 (or FT3) and FT4 within the normal range can also be enrolled;
• •FBG of patients without type 2 diabetes ≤ 126 mg/dL or ≤ 7.0 mmol/L, and that of patients with type 2 diabetes ≤ 167 mg/dL or ≤ 9.3 mmol/L; Or glycosylated hemoglobin (HbA1c) ≤8%;
• •If there is a risk of pregnancy, all patient (male or female) are required to take appropriate methods for contraception during the study until the 6th month post the last administration of study drug;
• •Well compliance, cooperate with follow-up;
• •Diaginosied or suspected of having an active autoimmune disease;
• •patients with poorly controlled pleural effusion, pericardial effusion, or ascites requiring repeated drainage, or received pleural effusion or ascites treatment within the past 3 months;
• •History of significant cardiovascular and cerebrovascular disease occurred in the 6 months prior to screening,Any of the following cardiac criteria:
• •* Mean resting corrected QT interval (QTc) \> 470 ms;
• •* Left ventricular ejection fraction (LVEF) ≤ 50%;
• •* American New York heart association (NYHA) heart function ≥ 2 or higher;
• •* serious arrhythmia;
• •* poorly controlled hypertension;
• •* other serious heart disease;
• •Patients with interstitial pneumonia, except those inactive and do not require hormone therapy disease;
• •Patients diagnosed with active infections that are poorly controlled by systemic treatment;
• •Any of the following test results are positive: human immunodeficiency virus (HIV) antibody, treponema pallidum antibody, hepatitis C virus (HCV) antibody, hepatitis B virus (HBV) surface antigen (HBsAg), HBV DNA and novel coronavirus nucleic acid;
• •Active tuberculosis (TB) during screening;
• •Treatment with systemic steroids or other immunosuppressive agents within 14 days prior to screening;
• •Vaccination within 4 weeks prior to screening;
• •Major injuries and/or surgery =\< 4 weeks prior to screening;
• •Persons with a history of psychotropic substance abuse and inability to abstain or with a history of mental disorders;
• •Pregnant or lactating women;
• •Skin diseases, such as psoriasis, may prevent intradermal vaccines from reaching the target area;
• •Other conditions regimented at investigators' discretion.