WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Exclusion Criteria

• •Receipt of investigational agents within =\< 2 weeks prior to registration
• •Prior receipt of gene therapy, at any time
• •Prior receipt of bevacizumab, at any time
• •Prior receipt of Gliadel, at any time
• •Patients who are on active therapy with Optune and who are unable to safely discontinue Optune prior to initiating trial therapy Note: Patients who can safely discontinue Optune prior to initiating trial therapy may participate
• •Patients who are on active therapeutic anti-cancer therapy and who are unable to discontinue the anti-cancer therapy prior to initiating trial therapy Note: Patients who discontinue anti-cancer therapy prior to initiating trial therapy may participate. Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen for this trial may participate
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to WP1066 or its excipients
• •Human immunodeficiency virus (HIV)-positive patients receiving combination antiretroviral therapy Note: These patients are ineligible because of the potential for pharmacokinetic interactions with WP1066. (HIV testing is not required, unless mandated by a local health authority.)
• •Patients who have received drugs that significantly interact with CYP450 enzyme(s) within =\< 2 weeks prior to planned first study treatment day Note: Patients who are able to safely discontinue the aforementioned agents \> 2 weeks prior to initiating treatment with WP1066 may participate. The enzymatic metabolism profile of WP1066 is unknown. Drugs that have a minor interaction with CYP450 are allowed, and drugs with a moderate interaction are allowed at the principal investigators (PI's) discretion. Zofran (ondansetron) is allowed
• •Patients who have received any of the following agents within 7 days of planned first study treatment day:
• •* Agents that are predominantly CYP2D6, 2C9, or 2C19 substrates
• •* Agents that are strong inhibitors or inducers of CYP2D6, 2C9, or 2C19
• •* Agents that are sensitive substrates of CYP3A4 with narrow therapeutic range Note: Patients who are able to safely discontinue the aforementioned agents \> 7 days prior to initiating treatment with WP1066 may participate. The enzymatic metabolism profile of WP1066 is unknown. Drugs that are minor CYP2D6, 2C9 or 2C19 substrates; minor inhibitors or inducers of CYP2D6, 2C9, or 2C19; or minor substrates of CYP3A4 are allowed. Moderate drugs will be allowed per PI's discretion. Zofran (ondansetron) is allowed
• •Patients on corticosteroids who require escalation of the corticosteroid dose Note: Patients receiving a stable or decreasing dose for at least one week may participate. Zofran (ondansetron) is allowed
• •History of brain hemorrhage, unless the following exception is met:
• •* Exception: Small, asymptomatic brain hemorrhage may be permitted, provided written documentation of PI approval has been obtained Note: The potential for further hemorrhaging with the use of WP1066 is unknown. It will be at the PIs discretion to enroll a patient who has a small, asymptomatic brain hemorrhage, but patients who have had symptomatic hemorrhages will be excluded
• •Uncontrolled seizures or seizure requiring escalation or addition of anti-epileptic drug
• •Lesion(s) larger than 50 mm in maximal diameter on MRI, or with midline shift exceeding 5 mm, or with hydrocephalus
• •Diffuse leptomeningeal disease Note: Because one of the objectives is PFS based on radiographic volumetric analysis of the tumor, the presence of diffuse leptomeningeal disease is excluded. This is secondary to the inadequacy of measuring the extent of the tumor burden within this setting and the very poor prognosis of these patients
• •Corrected QT (QTc) B interval \>= 450 ms These patients are excluded because the cardiac toxicities of WP1066 are unknown. Concomitant use of agents that prolong the QT interval should be avoided whenever feasible, or used with caution. Zofran (ondansetron) is allowed
• •Subjects who are at increased risk for radiation therapy (RT)-associated toxicities, such as those with known active collagen vascular disease (e.g., scleroderma, Sjogren's disease, etc.) or other inherited RT-hypersensitivity syndromes (e.g., Gorlin syndrome, Fanconi anemia, ataxia-telangiectasia, etc.)
• •For female patients of childbearing potential only:
• •Patients with a positive serum beta-human chorionic gonadotropin (HCG) pregnancy test within =\< 2 days prior to planned start date for trial therapy or who are immediately planning to become pregnant
• •Breastfeeding patients who are unwilling/unable to discontinue breastfeeding while receiving WP1066 Note: Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with WP1066, breastfeeding should be discontinued if the mother is treated with WP1066. Patients who discontinue breastfeeding prior to initiating treatment with WP1066 may participate
• •Uncontrolled intercurrent illness or condition including, but not limited to any of the following:
• •Ongoing or active infection requiring systemic treatment, except uncomplicated urinary tract infection;
• •Symptomatic congestive heart failure
• •Unstable angina pectoris
• •Cardiac arrhythmia
• •Psychiatric illness/social situation that would limit compliance with study requirements
• •Any other illness or condition that the treating investigator feels would interfere with study compliance or would compromise the subject's safety or study endpoints