Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

Inclusion Criteria

• •Participants \>= 18 years
• •Karnofsky Performance Scale (KPS) \>= 60
• •Negative pregnancy test done =\< 7 days prior to registration, for persons of childbearing potential only
• •Patients with a previous histological diagnosis of glioblastoma multiforme, isocitrate dehydrogenase (IDH) wildtype (WT) or astrocytoma, IDH-mutant World Health Organization (WHO) grade IV according to the 2021 WHO classification of tumors of the central nervous system , who are candidates to- and will undergo a redo craniotomy for excision of recurrent tumor
• •There is measurable disease according to the immunotherapy response assessment in neuro-oncology (iRANO) criteria
• •Serum creatinine and urea \<= 2 times the upper limit of normal (=\< 3 weeks prior to registration)
• •Alanine transaminase (ALT), aspartate transferase (AST) and alkaline phosphatase =\< 3 times the upper limit of normal, and bilirubin =\< 2.5 mg/dL (=\< 3 weeks prior to registration)
• •Prothrombin time =\< 1.5 times upper limit of normal (=\< 3 weeks prior to registration)
• •International normalized ratio (INR) and partial thromboplastin time (PTT) =\< 1.5 times the upper limit of normal (=\< 3 weeks prior to registration)
• •Hemoglobin \>= 9 g/dL (=\< 3 weeks prior to registration)
• •Platelets \>= 100 x 10\^9/L (=\< 3 weeks prior to registration)
• •Absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L (=\< 3 weeks prior to registration)
• •Willing to return to enrolling institution for follow-up (during the active monitoring phase of the study)
• •Patient or legally authorized representative (LAR) is able to fully understand and provide written and verbal consent for the protocol
• •Willingness to provide mandatory blood specimens for correlative research
• •Willingness to provide mandatory tissue specimens for correlative research
• •Willingness to undergo Ommaya reservoir placement and provide cerebrospinal fluid (CSF) samples for correlative research