Drug-coated Balloons in Big de Novo Coronary Disease

Exclusion Criteria

• •Patients with acute ST-segment elevation myocardial infarction/non-ST-segment elevation myocardial infarction within 3 months;
• •Hypersensitivity to the investigational balloon/stent system or concomitant medications required by the protocol;
• •Intolerant of dual antiplatelet therapy, or clinical conditions requiring long-term use of oral anticoagulants;
• •Life expectancy is less than 12 months;
• •eGFR≤30ml/min/1.73m2 or blood purification treatment;
• •LVEF≤40% or NYHA cardiac function class≥III;
• •Clinical conditions of severe hepatic insufficiency and coagulation disorder
• •Pregnant or breastfeeding women;
• •Participating in another clinical trial and have not completed the primary endpoint observation of the trial;
• •Reference lumen diameter \> 4.0mm;
• •Branch vessels ≥ 2.0 mm in diameter that may require intervention in the target lesion;
• •The vessel where the target lesion is located has an independent lesion with a diameter stenosis of ≥50% and requires interventional therapy;
• •Chronic total occlusive disease;
• •Left main stem disease;
• •Severe calcification, tortuous blood vessels, existing dissection or severe thrombus burden, the investigator judges that DCB is not suitable for treatment of lesions;
• •Lesions with failed preprocessing, or lesions whose length exceeds the length of a single DES/DCB need to be covered after preprocessing