Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)

Exclusion Criteria

• •1. Individuals who are during pregnant, lactation or menopause.
• •2. Individuals who had non-46-XX karyotype, or attributed to known genetic etiology.
• •3. Individuals who had pelvic surgery.
• •4. Cancer patients or receiving chemo/radiotherapy treatment within the past 5 years.
• •5. Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc.
• •6. Individuals who currently receiving weight-loss drugs or surgery or within the past 2 months.
• •7. Use of medications or traditional Chinese medicine that affect hormone levels, appetite, carbohydrate absorption, and metabolism within the past 3 months.
• •8. Individuals who take niacin, nicotinamide, or other vitamin B3-related supplementation, or other supplementation such as coenzyme Q10, vitamin E currently or within the past 3 months.
• •9. Use of antibiotics, probiotics, or prebiotics that affect the flora within the past 3 months.
• •10. Individuals with severe liver diseases or kidney disease that are ineligible to participate in the study.
• •11. A medical history of severe cardiovascular and cerebrovascular diseases.
• •12. Individuals who currently suffer from severe gastrointestinal diseases or undergo gastrointestinal resection that may affect nutrient absorption.
• •13. Individuals who drink more than 15g of alcohol per day or have a smoking habit.
• •14. Individuals who need drug treatment for any mental illness such as epilepsy and depression.
• •15. Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc.
• •16. Unable or unwilling to follow the study protocol.