The Effect of VitC on IVF Outcome of DOR Patients

Exclusion Criteria

• •PGT (preimplantation genetic testing) candidates
• •DOR caused by ovarian surgery, cancer radiotherapy/chemotherapy
• •Other ovulation disorders (e.g., PCOS, Cushing's syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia) or endometriosis (chocolate cysts)
• •Severe thyroid disorders: Hyperthyroidism, Graves' disease, Hashimoto's thyroiditis
• •Acute/chronic renal insufficiency, hemodialysis, or history of severe kidney impairment
• •Infectious diseases: HIV, active hepatitis, metabolic acidosis, tuberculosis, etc.
• •Severe autoimmune diseases (e.g., rheumatoid arthritis, lupus, Crohn's disease)
• •Cardiovascular events within the past 3 months: Coronary artery disease/myocardial infarction/clinically significant congestive heart failure；Stroke/transient ischemic attack (TIA)；Deep vein thrombosis/pulmonary embolism；Poorly controlled hypertension (SBP ≥160 mmHg or DBP ≥90 mmHg)；Diagnosed diabetes mellitus；Coronary intervention (PCI) or coronary artery bypass grafting (CABG)；
• •Neurological disorders (e.g., dementia,Alzheimer's, Parkinson's) or use of related medications
• •Psychiatric disorders or use of antiepileptic/antidepressant drugs
• •History of cancer or radiotherapy/chemotherapy
• •Allergy to vitamin C
• •Current high-dose vitamin C supplementation (\>500 mg/day)
• •Unwillingness to take the study-provided supplements
• •Alcohol abuse, smoking, or drug addiction
• •Participation in other clinical trials within the past month