Sponsors

Lead Sponsor

University Hospitals Cleveland Medical Center

Age

40 - No limit years

Sex

MALE

Healthy Volunteers

No

Inclusion Criteria

•Males age \> 40
•Patients diagnosed with Benign Prostatic Hyperplasia (BPH) and referred for HoLEP surgery
•Lower urinary tract symptoms (LUTS) of Overactive Bladder Syndrome (OABS) frequency - urgency - urge incontinence episodes - dysuria - nocturia and eligible for bladder botox injections
•International Prostate Symptom Score (IPSS) ≥ 17
•Overactive Bladder Symptom Score (OABSS) ≥ 7
•Participants have failed, are intolerant, or bad candidates for anticholinergic medication treatment for OAB

Exclusion Criteria

•History of bladder/prostate cancer
•History of pelvic radiotherapy
•History of neurological diseases
•Presence of active Urinary Tract Infection (UTI)
•Previous Bladder Outlet Procedure (Transurethral resection of prostate (TURP) Transurethral Incision of Prostate (TUIP) - UroLift, etc..)
•History of adverse reaction to Botox injections
•Post-void residual (PVR) greater than 300 ml
•History of clean intermittent catheterization
•Patients unable to stop anticoagulation of antiplatelet inhibitors 3 days prior to procedure

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