First Line Prevent Age Study

Exclusion Criteria

• •Age up to 18 years;
• •Severe or moderate comorbidities;
• •Rheumatological (systemic / autoimmune) diseases of any severity;
• •Intestinal infections (within 3 months);
• •SARS / pneumonia, other diseases accompanied by systemic inflammation during the last 2 months;
• •Chronic inflammatory bowel disease;
• •Major surgery within the last 3 months
• •Intoxication (alcohol, drugs, other toxins);
• •Oncological disease (except for basalioma) out of remission;
• •Persons with mental illness;
• •Diabetes;
• •Syndrome of obstructive sleep apnea of moderate and severe severity;
• •Low adherence to lifestyle interventions, including physical activity of less than 150 minutes of aerobic activity per week (at least two days per week) or 75 minutes of vigorous exercise (at least 3 days per week).