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COMPLETEDPhase 2NCT04865731

Dermaprazole Cream for Radiation Dermatitis in Head and Neck Cancer

In this study, the study team seek to conduct a pilot clinical study to evaluate the safety and efficacy of a reformulated proton pump inhibitor (PPI) cream (Dermaprazole) in definitive head and neck ...

Lead sponsor: The University of Texas Health Science Center at San Antonio•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

The University of Texas Health Science Center at San Antonio

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patients with head and neck malignancy (including radiation therapy to primary head cancers of any histology and/or neck lymphatics, excluding brain malignancies)
•Biopsy proven diagnosis of head and neck malignancy
•Planned to receive definitive chemoradiation of at least 66Gy
•Age 18 years or older
•Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2
•Written Informed Consent
•History and Physical within 12 weeks of enrollment
•Lack of concurrent chemotherapy
•Open wound at time of simulation
•Known autoimmune, connective tissue, or skin disorder; or other theoretical radiosensitivity to include bullous pemphigoid, dermatomyositis, lupus of the skin and scleroderma

Exclusion Criteria

•Prior head and neck radiotherapy
•Neoadjuvant chemotherapy
•Any serious medical condition or illness that would preclude the safe administration of the trial treatment including, but not limited to, active infection, symptomatic heart failure, unstable angina, psychiatric illness or social situations that would limit compliance with treatment

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 6, 2025Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE2

Enrollment6

Start dateJun 2022

Last updatedAug 6, 2025

Condition

Cancer of the Head and Neck

Locations shown

Mays Cancer Center

San Antonio, Texas

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 6, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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