Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor

Exclusion Criteria

• •Pregnancy or lactation
• •Drug addiction defined as any use of cannabis, opioids or other addictive drugs
• •Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.).
• •Lack of ability to cooperate
• •Current use of medications that may affect the trial such as antihistamines, antipsychotics and pain killers, as well as systemic or topical steroids.
• •Skin diseases
• •Moles, scars or tattoos in the area to be treated or tested.
• •Hypersensitivity to papaya and mango fruit, cashew nuts, rubber latex
• •Consumption of alcohol or painkillers 24 hours before the study days and between these
• •Acute or chronic pain
• •Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)