Role of Interleukin-13 Pathways on Pain and Itch Sensitivity

Exclusion Criteria

• •Pregnancy or lactation
• •Drug addiction defined as any use of cannabis, opioids, or other drugs
• •Previous or current history of neurological, dermatological (e.g., AD, psoriasis, etc.), immunological, musculoskeletal, cardiac disorder, or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.)
• •Moles, wounds, scars, or tattoos in the area to be treated or tested
• •Current use of medications that may affect the trial such as antihistamines and pain killers (use of antihistamines should be discontinued 72 hours before the experiment and all topical agents and emollients should be discontinued 24 hours before the experiment).
• •Use of systemic and topical corticosteroids
• •Consumption of alcohol or painkillers 24 hours before the study days and between these
• •Acute or chronic pain
• •Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)
• •Lack of ability to cooperate