A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)

Exclusion Criteria

• •Clinically significant pulmonary disease other than chronic obstructive pulmonary disease (COPD)
• •Clinically significant comorbid medical conditions or infections that, in the investigator's judgment, could affect participant safety or interfere with study conduct
• •Clinically significant cardiovascular disease
• •Recent respiratory infection or COPD exacerbation
• •Exposure to approved or experimental biologic therapies for COPD with less than 5 half-life washout period
• •Pregnancy or breastfeeding
• •Smoking or diagnosed substance use disorder
• •Any condition or circumstance that, in the investigator's opinion, would make participation unsafe or compromise study integrity