Puberty Suppression and Cardiometabolic Health

Exclusion Criteria

• •Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures
• •Type 1 or 2 diabetes (by medical history)
• •On any medications that affect insulin sensitivity (e.g. metformin, antipsychotics)
• •Hypertension (resting BP ≥ 140/90 mm/Hg)
• •Weight \> 400 lbs
• •On estrogen- or progesterone-containing medications at baseline
• •\>3 hours of moderate-to-vigorous physical activity on the 3DPAR at the screening visit