Annette Bellar

CONTACT

Lead Sponsor

The Cleveland Clinic

Age

21 - 65 years

Sex

ALL

Healthy Volunteers

Yes

•Inclusion of Subjects with Alcoholic Hepatitis (AH):
•\*diagnosis of AH either by imaging, biochemical values or liver biopsy as well as drinking history
•Inclusion Heavy Drinking Controls:
•\*heavy alcohol drinking will be defined as \>40 g/day or \>280g/week on average for women and \>60 g/day or \>420 g/week on average for men for a minimum of 6 months \[6\] and within the 4 weeks prior to study enrollment.

•inability or unwillingness to sign informed consent
•cancer
•autoimmune disease that in the opinion of the PI will confound study data
•Control subjects (drinking and non drinking) must meet the following criteria:
•INR \< 1.4
•total bilirubin levels must \<3
•no prior history of known alcoholic liver disease
•absence of hepatosplenomegaly (from physical examination or radiographic imaging) or stigmata of liver disease.