No history of anti-cancer therapy, or adjuvant/neo-adjuvant chemotherapy for non-metastatic tumor finished for more than 6 months before enrollment;
For the female subject with productive ability, urine pregnancy test must be done and is negative within 7 days before enrollment;
No history of serious allergic to biologic agents, especially E.Coli products;
The authorized ICF must be signed.
You may not be if
Woman in pregnancy and breast-feeding, or having productive ability without contraception;
Having the serious acute infection uncontrolled or purulent/chronic infection with unhealed wound;
Having the serious heart disease, including congestive heart failure, uncontrolled high-risk arrhythmia, unstable angina, myocardial infarction, valvular disease, and refractory hypertension;
Having uncontrolled nervous or mental disease with low compliance and reluctance to description of response; uncontrolled primary brain tumor or other metastatic brain cancer with obvious intracranial hypertension or mental symptoms;
Having the tendency of bleeding, such as FIB≤2G/L;
Being receiving adjuvant chemotherapy;
On other conditions investigator considers, the subject is not fitful to participate the trial.
