Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide

Exclusion Criteria

• •Age: Under 21 or over 70 y.o.
• •BMI: \>35 for T2D and \>30 for ND
• •Hypertension
• •Severe polydipsia and polyuria
• •Uncontrolled hyperlipidemia
• •Clinically significant liver dysfunction
• •Clinically significant kidney dysfunction
• •Anemia
• •Clinically significant leukocytosis or leukopenia
• •Clinically significant thrombocytopenia or thrombocytosis
• •Coagulopathy
• •Positive urine drug screen
• •Urinalysis: Clinically significant abnormalities
• •Clinically significant electrolyte abnormalities
• •Smoking \>10 cig/day
• •Alcohol: Men \>14 drinks/wk or \> 4 drinks/day, Women \>7 drinks/wk or \>3 drinks/day
• •History of chronic liver disease, active hepatitis infection, HIV/AIDS, chronic kidney disease (stage 3 or greater), active cancer, cardiovascular disease or other heart disease, systemic rheumatologic conditions, seizures, bleeding disorders, muscle disease
• •Surgeries that involve removal of endocrine glands except for thyroidectomy
• •Pregnant women
• •Subject enrolled in another study less than one month prior to the anticipated start date of the proposed study
• •Family history: family history of premature cardiac death
• •Allergies to medication administered during study
• •Uncontrolled psychiatric disorders
• •Perimenopausal women who are experiencing/have experienced hot flashes
• •Any contraindications for MRI: presence of any non-MRI compatible implants including pacemaker, aneurysm clip, cochlear implant, neurostimulator; history of eye injury with metal; history of ever being a metal worker; history of gunshot wounds or any other imbedded metal objects; history of claustrophobia or prior episodes of significant anxiety or discomfort while obtaining an MRI.
• •Any condition which in the opinion of the PI makes the subject ill-suited for participation in the study