Collection of Human Metabolic Tissues

Inclusion Criteria

• •1. Written informed consent
• •2. Age 18 - 65 years inclusive at surgery
• •3. IMC \> 35
• •4. Subject qualified for bariatric surgery (sleeve gastrectomy or gastric bypass)
• •5. Specific criteria :
• •* Type 2 diabetes group (D) (90 patients) : type 2 diabetes according to ADA criteria
• •* Insulin resistance non diabetes group (IR) (80 patients) : HOMA-IR criteria ≥ 3
• •* Insulin Sensitivity non diabetes group (N) (100 patients) : N1.HOMA-IR criteria \< 3
• •1. Vulnerability according to article L1121-6 of the Public Health Code
• •2. Protected adult or unability to give consent according to article L1121-8 of the Public Health Code
• •3. Unability to understand the design and aims of the study or to communicate with the investigator
• •4. Non affiliation to a social security system
• •5. Prior bariatric surgery (except lap-band procedure)
• •6. Serologic profile indicating hepatitis B, hepatitis C or HIV infection
• •7. Inflammatory, infectious or autoimmune disease (current or in the previous 3 month)
• •8. Malignancies within 5 years prior to inclusion or not considered as treated curatively
• •9. Concomitant use of steroids or NSAI or use in the 8 days before surgery
• •10. alcohol abuse/addiction
• •11. Anticipated poor compliance to study procedures
• •12. Other type of diabetes than type 2