Exercise, Fitness and Tumor Profiling in Breast Cancer Patients

Exclusion Criteria

• •Cohort 1:
• •Received any form of neoadjuvant treatment
• •Presence of any other concurrent, actively treated malignancy
• •Presence of metastatic disease
• •If performing a CPET, any of the following contraindications:
• •* Acute myocardial infarction within 3-5 days of any planned study procedures;
• •* Unstable angina
• •* Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
• •* Recurrent syncope
• •* Active endocarditis
• •* Acute myocarditis or pericarditis
• •* Symptomatic severe aortic stenosis
• •* Uncontrolled heart failure
• •* Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures
• •* Thrombosis of lower extremities
• •* Suspected dissecting aneurysm
• •* Uncontrolled asthma
• •* Pulmonary edema
• •* Respiratory failure
• •* Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis).
• •Mental impairment leading to inability to cooperate
• •If performing a CPET, room air desaturation at rest ≤ 85%
• •Any other condition or intercurrent illness that, in the opinion of the investigator, makes the participant a poor candidate for the study.
• •Cohort 2:
• •Use of any selective estrogen receptor modulator or aromatase inhibitor within 6 months of consent, including, but not limited to: tamoxifen, raloxifene, arzoxifene, acolbifene, anastrozole, exemestane, and letrozole.
• •Enrollment on an interventional investigational study
• •Bilateral breast implants
• •History of any of the following:
• •* Invasive breast cancer
• •* DCIS
• •Any current invasive cancer diagnosis
• •Metastatic malignancy of any kind
• •If performing a CPET, any of the following contraindications:
• •* Acute myocardial infarction within 3-5 days of any planned study procedures;
• •* Unstable angina
• •* Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
• •* Recurrent syncope
• •* Active endocarditis
• •* Acute myocarditis or pericarditis
• •* Symptomatic severe aortic stenosis
• •* Uncontrolled heart failure
• •* Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures
• •* Thrombosis of lower extremities
• •* Suspected dissecting aneurysm
• •* Uncontrolled asthma
• •* Pulmonary edema
• •* Respiratory failure
• •* Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis).
• •Mental impairment leading to inability to cooperate
• •If performing a CPET, room air desaturation at rest ≤ 85%
• •Any other condition or intercurrent illness that, in the opinion of the investigator, makes the participant a poor candidate for the core biopsy or the study.