To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

Inclusion Criteria

• •Documented ER +/ HER2- tumor according to American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines
• •Disease progression after or during treatment with a combination of CDK4/6i and endocrine therapy: \<= 1 prior lines of systemic therapy in the locally advanced (recurrent or progressed) or metastatic setting
• •Measurable or evaluable disease per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1)
• •Participants for whom endocrine-based therapy is recommended and treatment with cytotoxic chemotherapy is not indicated at time of entry into the study, as per national or local treatment guidelines
• •Confirmation of biomarker eligibility: presence of \>= 1 study-eligible PIK3CA mutation
• •Life expectancy of \> 6 months
• •Ability, in the investigator's judgment, and willingness to comply with all study -related procedures, including completion of patient-reported outcomes