Lead Sponsor

Kristian Karstoft

Collaborators

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

•Glucose-lowering-medication naïve T2D and/or subjects with impaired glucose tolerance defined as: 2-h plasma glucose (PG) in the 75-g OGTT (7.8-11.0 mmol/L) and/or HbA1c (39-47 mmol/mol)
•Caucasian
•BMI \> 25 but \< 40 kg/m2
•Low to moderate physically active (≤90 min of structured physical activity/week)

•Pregnancy
•Smoking
•Glucose-lowering treatment
•Treatment with steroids and other immunomodulating drugs
•Contraindication to increased levels of physical activity
•Liver disease (ALAT elevated more than 3 times above upper normal limit, or reduced levels of the liver function markers albumin and KF II+VII+X)
•Renal insufficiency (eGFR\<60 ml/min)
•Prior history of lactic acidosis
•HbA1c \>55 mmol/mol and/or 2-hPG in the 75-g OGTT \> 15 mmol/L