Dexmedetomidine Combined With Lidocaine Infusion Affect Inflammation Cytokines

Exclusion Criteria

• •a history of allergy to local anesthetics
• •severe respiratory, renal or hepatic disease
• •preoperative opioids medication
• •psychiatric medical history
• •Patients with severe hypotension \[mean arterial pressure (MAP\<60 mmHg)\] or bradycardia \[heart rate (HR) \<40 beats per minute (bpm)\], arrhythmia, or urticaria due to lidocaine and dexmedetomidine infusion during the surgery