Efficacy of Gabapentin in Alcohol Dependency Treatment

Exclusion Criteria

• •having major psychiatric disorders including schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder, or suicide risk based on a clinical interview by attending psychiatrist
• •receiving other medications not in the protocol of the study for any reasons or having history of using other substances including methamphetamine, heroin, cannabis, inhalants, mitragyna speciosa (or kratom in Thai), except tobacco based on self-report
• •having a medical disease, e.g. essential hypertension, diabetes, renal (e.g., normal renal test) or liver disease (e.g., liver function test was not higher than two times of normal range and gamma-glutamyl transferase (GGT) is less than 800 U/L), epilepsy, stroke
• •having history of alcohol withdrawal seizure or delirium based on clinical interview by attending psychiatrist
• •having moderate to severe alcohol withdrawal symptoms based on score \>13 of the Clinical Interview for Withdrawal Alcohol Arlington (CIWA - Ar) at the time of recruitment
• •having cognitive impairment based on score \< 24 from the Mini Mental State Exam (MMSE)
• •having history of allergy to gabapentin
• •pregnancy or breast feeding.