Approach-Avoidance and Alcohol Challenge Study in PTSD

Exclusion Criteria

• •* history of significant medical illness, particularly if possible changes in cerebral tissue
• •* neurologic abnormality including significant head trauma (loss of consciousness of ≥5-min)
• •* full Scale IQ \<85
• •* contraindication to MRI scanning
• •* positive pregnancy test
• •* severe alcohol use disorder
• •* current severe cannabis use disorder
• •* any current substance use disorder (other than alcohol, cannabis, or nicotine)
• •* scores \> 15 on the alcohol Use Disorders Identification Test (AUDIT; part of phone screen)
• •* ever being in an abstinence-oriented treatment program for alcohol use
• •* reporting wanting to quit drinking but not being able to
• •* any medical, religious, or other reasons for not drinking alcohol
• •* history of heart attack, heart trouble, high blood pressure, diabetes, or liver disease
• •* an adverse reaction to alcoholic beverages
• •* reporting never consuming 4 (men) or 3 (women) or more drinks on at least two occasions over the last year
• •* unwillingness to have a friend or family member drive them home after the alcohol administration sessions
• •* not taking medications for \>4 weeks (i.e. participants must be stable on meds)
• •* acute suicidality with intent
• •\- history of PTSD
• •* any prior psychiatric hospitalizations
• •* lifetime history of a neurodevelopmental disorder, affective disorder, psychotic disorder, suicide attempt, or eating disorder
• •* greater than 1 month of lifetime psychotropic medication