Effect of a Modified Ketogenic-Mediterranean Diet on Alzheimer's Disease

Exclusion Criteria

• •1. Diagnosis of neurodegenerative illness (except for MCI or early AD in the MCI/eAD group);
• •2. History of a clinically significant stroke;
• •3. Current evidence or history in past year of focal brain lesion, head injury with loss of consciousness or DSM-IV criteria for any major psychiatric disorder including psychosis, major depression, bipolar disorder, alcohol or substance abuse;
• •4. Sensory impairment (i.e.: visual or auditory) that would preclude the participant from participating in the protocol;
• •5. Diabetes that requires current use of diabetes medications;
• •6. Current use of cholesterol/lipid lowering medications;
• •7. Clinically significant elevations in liver function tests;
• •8. Active neoplastic disease (stable prostate cancer and non-melanoma skin cancer is permissible);
• •9. History of epilepsy or seizure within past year;
• •10. Contraindications for MRI (claustrophobia, craniofacial metal implants, pacemakers);
• •11. Significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease;
• •12. Use of the following medications: anticonvulsants, drugs with potential interfering CNS effects (other than cholinesterase inhibitors or memantine), medications with significant anticholinergic activity, anti-parkinsonian medications or regular use of narcotic analgesics;
• •13. If female, menstruation in the past 12 months or hysterectomy and current hormone replacement therapy medication;
• •14. Major digestive disorders, absorption issues, or surgeries that may be exacerbated by diet changes;
• •15. Untreated hypothyroidism or B12 deficiency;
• •16. Participants currently using resveratrol, CoQ10 (coenzyme Q10), coconut oil/other medium chain triglyceride-containing (ie: Axona) supplements, or curcumin will be excluded unless they are willing to discontinue them 2 weeks prior to the start of baseline visits and remain off for study duration.