The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure

Exclusion Criteria

• •Females who are currently pregnant or planning to become pregnant during the study period
• •Diagnosis of any other form of glaucoma other than open-angle
• •Intraocular pressure readings of \<14mmHg in either eye when measured during routine office visit in the past 12 months.
• •Schaffer angle grade \< 2 in either eye by gonioscopy
• •Intraocular surgery within 6 months or laser within 3 months
• •History of retinal tear or detachment in either eye
• •Active iritis in either eye as determined by most recent eye examination
• •Patients who smoke or have irregular daily sleep patterns
• •Patients who have started or changed glucocorticoids therapy in the last 3 months
• •Patients who are currently using medical or recreational marijuana
• •Any use of a non-FDA approved medication for glaucoma in the last 3 months