Lead Sponsor

Balance Therapeutics

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•Meets ICSD-3 criteria for IH or Narcolepsy Type 2 and not undergoing pharmacologic treatment for the condition
•Usual nightly total sleep at least 6 hours as single major rest period without naps
•Epworth Sleepiness Scale of 10 or greater
•Males or females age 18 to 65 years

•Any disorder causing hypersomnia other than IH or Narcolepsy Type 2
•Usual bedtime later than midnight
•Seizure disorder or history of syncope, unexplained loss of consciousness or seizure in the past 3 years
•Beck Depression Inventory score greater than 19
•Beck Anxiety Inventory score greater than 15
•Significant history of or current suicidal ideation or behavior
•BMI less than 18 kg/m2 or greater than 39 kg/m2
•Positive toxicology screen or breathalyzer test
•Clinically significant abnormal findings on safety assessments
•Any significant medical or psychiatric disease or any condition that would put the patient at risk by participating in the study