International Swiss Primary Hypersomnolence and Narcolepsy Cohort Study

Exclusion Criteria

• •Study participants and controls:
• •SDB for study participants and healthy controls: Presence of clinically significant and untreated obstructive sleep apnea (OSA) or central sleep apnea (CSA) as determined by the investigator or documented previously; or documentation of one of the following:
• •* Apnea index (AI) \> 10 if on OSA treatment or untreated; or
• •* Clinically significant hypoventilation; or
• •* Noncompliance with primary OSA therapy
• •* except if NT1 has been diagnosed including decreased or missing cerebrospinal fluid (CSF) hypocretin
• •SDB for control population with SDB:
• •* Central Sleep Apnea (CSA)
• •* Noncompliance with primary OSA therapy and/or
• •* No reported improvement of EDS and/or H within 3 months of positive airway pressure (PAP) treatment
• •The following disorders/conditions that on clinical grounds are considered to be the cause of EDS / H
• •* Other sleep disorders (e.g. Restless legs syndrome (RLS) with periodic leg movement syndrome (PLMS), sleepwalking, clear-cut circadian disorder)
• •* Other neurological disorders (e.g. stroke, multiple sclerosis, parkinsonism, severe traumatic brain injury)
• •* (Auto-)immune and systemic disorders (such as Hashimoto Thyroiditis, Chron's Disease, ulcerous colitis, Diabetes mellitus type I, Systemic lupus erythematosus)
• •* Malignancy (except: Status in Remission for at least \> 10 years)
• •* Instable psychiatric disorder (e.g. acute psychotic, acute suicidal, episode of major depression requiring in-hospital treatment, active substance abuse)
• •* Active infectious disease at screening
• •* Permanent medications / drugs
• •Chronic infectious diseases (such as Hepatitis B/C, HIV)
• •Chronic use of antibiotics
• •Recent use (\< 8 weeks) of immune-modulating drugs
• •Healthy controls additional:
• •Subjective complaints of EDS and / or H
• •ESS \> 10
• •Polysomnography (PSG) with AI \> 10/h and / or PLMS Index \> 30/h
• •MSLT mean Sleep Latency \< 12 min