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Metformin in Non Small Cell Lung Cancer (NSCLC) | Clinical Trials | Clareo Health

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TERMINATEDPhase 2NCT02285855

Metformin in Non Small Cell Lung Cancer (NSCLC)

The goal of this clinical research study is to learn if giving metformin in combination with radiation therapy is more effective than radiation therapy alone. In this study, participants will receive ...

Lead sponsor: M.D. Anderson Cancer Center•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

M.D. Anderson Cancer Center

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•1. Patients with pathologic diagnosis of lung NSCLC or squamous cell carcinoma.
•2. Patients are to be treated with hypofractionated RT.
•3. Patient is not a surgical candidate due to medical comorbidities determined by a thoracic surgeon or patient refusal
•4. Patient plans to receive treatment at MD Anderson
•5. Patients must sign informed consent
•6. Patient must have adequate renal function within 30 days prior to registration, defined as serum creatinine within normal institutional limits or creatinine clearance at least 60 ml/min

Exclusion Criteria

•1. Patient has: random glucose \>200 mg/dl or is taking an oral hypoglycemic agent or insulin at the time of study entry
•2. Patient has a history of lactic acidosis, chronic kidney disease or a creatinine \>/= 1.2 mg/dl
•3. Women who are pregnant or breast feeding, as treatment involves unforeseeable risks to the participant, embryo, fetus, or nursing infant
•4. Patients with history of allergic reaction to metformin

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 6, 2020Terms

Trial snapshot

StatusTERMINATED

PhasePHASE2

Enrollment27

Start dateFeb 2015

Last updatedJan 6, 2020

Condition

Locations shown

University of Texas MD Anderson Cancer Center

Houston, Texas

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 6, 2020Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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