Supervised Aerobic Training During or After Chemotherapy for Operable Breast Cancer

Inclusion Criteria

• •Aged 21-80 years
• •Female
• •MSK histologically confirmed early-stage operable breast cancer
• •Scheduled to receive chemotherapy in the neoadjuvant or adjuvant setting
• •ECOG status of 0 or 1
• •Performing less than 150 minutes of structured moderate-intensity or strenuous intensity exercise per week
• •If a female of child-bearing potential, must not be pregnant or planning to become pregnant during the study.
• •a. Women \< 50 years old must have a negative pregnancy test (urine HCG or serum βHCG) within 2 weeks of beginning chemotherapy.
• •Able to complete an acceptable baseline cardiopulmonary exercise test (CPET), in the absence of high risk ECG findings or other inappropriate response to exercise as determined by the investigator.
• •Able to achieve an acceptable peak baseline CPET, as defined by any of the following criteria:
• •* Achieving a plateau in oxygen consumption, concurrent with an increase in power output;
• •* A respiratory exchange ratio ≥ 1.10;
• •* Attainment of maximal predicted heart rate (HRmax) (i.e., within 10 bpm of age-predicted HRmax \[HRmax = 220-Age\[years\]);
• •* Volitional exhaustion, as measured by a rating of perceived exertion (RPE) ≥ 18 on the BORG scale.
• •Willingness to be randomized to one of the study arms