The Effect of Paliperidone Palmitate in Schizophrenia

Exclusion Criteria

• •No history of antipsychotics prescription
• •History of NMS(Neuroleptic malignant syndrome)
• •Allergic reaction or hypersensitive reaction of risperidone or paliperidone ER
• •clozapine medication within 1 month before screening
• •SSRI, MAOI, TCA medication within 2 months
• •Lithium, valproic acid, carbamazepine, topiramate, lamotrigine medication starting within 2 months
• •patient who is supposed to be impossible to participate to this study due to clinical risk of suicide or aggressive behavior based on clinician's opinion
• •current or previous history of drug depedence according to DSM-IV
• •Pregnant or breast-feeding female patient
• •Significant biochemical or hematological abnormality or abnormal finding of urinalysis, based on clinician's opinion
• •history of cardiac disease, which is related to QT prolongation(sick sinus, complete AV block, CHF, ventricular tachycardia, hypokalemia or hypocalcemia)
• •History of participating to other investigational drug trial within 1month prior to screening
• •Investigator or employee at clinical trial center, personnel related to investigator or trial center on this or other study, or family of employee or investigator