Exploratory Study on the S-1 + Paclitaxel Chemotherapy for Unresectable Gastric Cancer

Inclusion Criteria

• •Unresectable gastric cancer as proven histologically (AJCC, Version 7) under any following condition: Unable radical excision due to the local metastasis or invasion Metastasis to the lymph node beside the abdominal aorta Non-extensive metastasis to liver (not more than three metastatic foci of radical excision)
• •Definitely diagnosed as above stage of stomach cancer before the operation via CT or MRI, ultrasonic endoscopy and blood tumor antigen test, or through the laparoscopy if necessary
• •Untreated (e.g. radiotherapy, chemotherapy, target therapy and immunotherapy)
• •ECOG (Eastern Cooperative Oncology Group) : 0\~2
• •Age: 18\~75 years old
• •Normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function). For example: WBC\>4.0×109/L, NEU \>1.5×109/L, PLT\>100×109/L, BIL\<1.5 times of upper limit of normal reference value, ALT and AST\<2.5 times of upper limit of normal reference value, and CRE\<1.2mg/dl
• •Good cardiac function before the recruitment, no seizure of myocardial infarction in past half year, and controllable hypertension and other coronary heart diseases
• •Not concomitant with other uncontrollable benign diseases before the recruitment (e.g. the infection in the lung, kidney and liver)
• •Not participating in other study projects before and during the treatment
• •Signed the Informed Consent Form
• •Distal metastasis to lung, brain and bone (except the liver)
• •Ever operation on the stomach
• •Operation intolerance due to other systemic basic diseases
• •Ever administered other drugs (including TCM drugs) before the recruitment, or no guarantee of progress according to the study requirement after the recruitment
• •Allergy to the drugs in this protocol
• •Pregnant or lactating women
• •Women at childbearing age and of pregnancy desire during the study