Imaging Cannabinoid CB1 Receptors in Schizophrenia

Exclusion Criteria

• •Patients with Schizophrenia:
• •1. Any serious medical condition as judged by the Principal Investigator.
• •2. The patient has a guardian or a Durable Power of Attorney.
• •3. Past or present diagnosis of primary mood disorders (such as bipolar illness or major depressive disorder). Any present substance abuse. Cannibis use within the last 2 months.
• •4. Diagnosis of alcohol abuse or alcohol dependence as defined by DSM-IV (American Psychiatric Association 1987) criteria. Recent heavy use of alcohol. That is, subjects must have an alcohol audit score of less than or equal to 9. In addition, subjects must agree not to consume any alcohol in the three days prior to the PET scan.
• •5. Positive test for HIV.
• •6. Metallic foreign bodies that would be affected by the MRI scanner magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
• •7. Head trauma resulting in a period of unconsciousness lasting longer than 1 hour.
• •8. History of fetal alcohol syndrome or other neurodevelopmental disorder.
• •9. History of seizures, other than in childhood and related to fever.
• •10. Recent exposure to radiation (i.e., PET from other research) which when combined with this study would be above the allowable limits.
• •11. Positive urine drug screen.
• •12. Pregnancy or breast feeding.
• •13. Inability to lie flat on camera bed for about 2.5 h
• •Healthy Subjects:
• •1. Any current Axis I diagnosis; and any past or present substance abuse other than a total lifetime use of cannabis of less than 10 times and no cannabis use within the last 3 months.
• •2. Family history of schizophrenia, schizophreniform disorder, or schizo-affective disorder.
• •3. Clinically significant laboratory abnormalities.
• •4. Recent heavy use of alcohol. That is, subjects must have an alcohol audit score of less than or equal to 9. In addition, subjects must agree not to consume any alcohol in the three days prior to the PET scan.
• •5. Psychotropic medication use (including benzodiazepines and illicit drugs) during the 28 days (42 day for fluoxetine) prior to the PET scan.
• •6. Serious medical problems.
• •7. Positive test for HIV.
• •8. Metallic foreign bodies that would be affected by the MRI magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
• •9. Head trauma resulting in a period of unconsciousness lasting longer than 10 minutes.
• •10. History of fetal alcohol syndrome or other neurodevelopmental disorder.
• •11. History of seizures, other than in childhood and related to fever.
• •12. Recent exposure to radiation (i.e., PET from other research) which when combined with this study would be above the allowable limits.
• •13. Positive urine drug screen.
• •14. Pregnancy or breast feeding.
• •15. Inability to lie flat on camera bed for about 2.5 h