Stereotactic Body Radiotherapy and Radiofrequency Ablation for Lung Tumors Near Central Airways

Inclusion Criteria

• •Histologically confirmed primary lung cancer, lung metastasis from another primary, or recurrent tumors in the setting of prior RFA or cryotherapy
• •Tumors \< 2 cm from trachea or zone of proximal bronchial tree (central tumors)
• •Each tumor \< 5 cm in size prior to treatment
• •Medically inoperable patients as determined at the multidisciplinary thoracic tumor board, or medically operable patients who refuse surgery
• •Criterion for medical inoperability include:
• •* Overall clinical assessment at the UCLA thoracic tumor board
• •* Reduced Pulmonary Function (FEV1, DLCO, etc) based on one major or two minor criterion as described below:
• •Modified ACOSOG Criteria for medical inoperability:
• •* Major Criteria: FEV1% \< 50% or \< 1L and DLCO \< 50%
• •* Minor Criteria: Age \> 75, FEV1 51-60% predicted, or FEV1 1-1.2L, DLCO 51%-60% predicted, pulmonary hypertension, poor left ventricular function (EF \< 40% or less), resting or exercise arterial pO2 \< 55 mmHg, and pCO2 \> 45 mmHg
• •Age \> 18 years old
• •KPS \> 70
• •If a woman is of childbearing potential, a negative urine or serum pregnancy test must be documented.
• •Ability to understand and the willingness to sign a written informed consent