Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)

Exclusion Criteria

• •Diabetes mellitus
• •Treatment with sevelamer within 3 months prior to enrollment
• •Acute, clinically significant inflammation within 1 month prior to enrollment
• •Pregnancy or breast-feeding
• •Clinically significant obstipation or bowel obstruction
• •Discontinuation of previous sevelamer treatment because of side effects
• •Expected time in HD \< 1 year
• •Unwillingness to undergo the investigations and follow-up required in the the protocol
• •Patients who have received any investigational drug within 1 month prior to enrolment
• •Participation in another study, which may interfere with the present study