Best Event Schizophrenia Trial--A Randomized Double-Blind Trial of Aripiprazole and Risperidone in Schizophrenia

Exclusion Criteria

• •1. Current active substance use disorder diagnosis or a history of cocaine abuse or dependence;
• •2. Female patients who are either pregnant or nursing;
• •3. Known history of mental retardation, seizure disorder, or a clinically significant head injury (prolonged loss of consciousness, neurological sequelae, or demonstrated structural brain injury);
• •4. Non-English speaking (mastery of English insufficient to participate in study evaluation procedures);
• •5. Serious, unstable medical illness;
• •6. Known hypersensitivity to any study medication;
• •7. Medical contraindication to any element of the study procedure;
• •8. Current symptoms which present serious risk of danger to self or others;
• •9. Participation in a clinical trial of an investigational drug within 30 days of study entry;
• •10. Current severity of psychiatric symptoms contraindicates a delay in initiation of antipsychotic medication treatment until functional imaging studies and neuropsychological testing have been completed;
• •11. Baseline QTc interval of \> 450 msec.