Circadian Rhythm of Erythropoietin And Melatonin in Renal Disease

Exclusion Criteria

• •Instable angina pectoris, heart failure NYHA class IV
• •Therapy with erythropoetin, melatonin and hypnotics
• •Acute renal failure or rapidly progressive glomerulonephritis
• •Bleeding or hemolysis as a cause of anemia
• •Deficiency of iron, folate and/or vitamin B12
• •Presence of chronic inflammatory disease or clinically significant infection
• •Hemoglobinopathies
• •Alcohol and/or drug abuse
• •Enrolment in another study
• •Any kind of disorder that compromises the ability of the subject to give written informed consent and/or to comply with study procedures