A Study in Sepsis Patients With Renal Failure

Inclusion Criteria

• •Patients between the age of 18 and 80 years.
• •Proven or suspected infection.
• •Two out of four SIRS criteria of systemic inflammation, existing for less than 24 hours after admission in the intensive care unit, as follows:
• •* Core temperature higher then 38 degree Celsius or lower then 36 degree Celsius.
• •* Heart rate above 90 beats/min (unless the patient has a medical condition known to increase heart rate or is receiving treatment that would prevent tachycardia).
• •* Respiratory rate above 20 breaths/min, a PaCO2 lower then 32mmHg or the use of mechanical ventilation for an acute respiratory process.
• •* White-cell count above 12,000/mm3 or below 4,000/mm3 or a differential count showing \>10 percent immature neutrophils.
• •Acute renal failure, defined as
• •* Rise in serum creatinine level to ≥150μmol/L within the previous 48 hours, in the absence of primary underlying renal disease OR
• •* Minimally a stage 1 Kidney Injury according to AKIN creatinine criteria: Increase in serum creatinine ≥26.2µmol/L (0.3mg/dL) or increase to ≥150% (≥1.5 -fold) from baseline in the previous 48 hours in the absence of primary underlying renal disease and where baseline creatinine is less than 150 µmol/L) OR
• •* Minimally a stage 1 Kidney Injury according to AKIN Urine Output criteria: Urine Output of ≤ 0.5mg/kg/h for ≥6h and following adequate fluid resuscitation when applicable, in the absence of underlying primary renal disease and where baseline creatinine is less than 150µmol/L)
• •Written informed consent obtained prior to any study intervention.